Mesenchymal Stem Cells (MSCs) are rare progenitor cells with multi-lineage differentiation potential, derived from sources such as the umbilical cord, adipose tissue, or bone marrow. These cells are highly valued in tissue engineering and cell-based therapies due to their ability to support hematopoiesis (blood cell production) and differentiate into various somatic cell types.
In vitro (lab-based) and in vivo (in living organisms) studies have confirmed their potential and expanded their range of therapeutic applications.
While autologous (self-derived) MSC therapies were more common in earlier stages, studies now show that allogeneic (donor-derived) MSCs can yield similar or even superior results. In this context, Umbilical Cord-derived MSCs (UC-MSCs) have become the most preferred type due to their therapeutic potential and safety in clinical applications.
UC-MSCs currently show promising results in the treatment of various conditions, including:
Stem cell applications have emerged in recent years as effective treatments, particularly for genetic and degenerative eye conditions. They are widely used in inherited diseases of the retina, optic nerve, and cornea.
Conditions treated include Retinitis Pigmentosa (night blindness), Stargardt macular dystrophy, dry age-related macular degeneration, and other degenerative retinal diseases.
For optic nerve disorders, cases include optic atrophy due to glaucoma, idiopathic causes, trauma, or other factors.
The stem cell treatment is applied via injection around the eye, under local or general anesthesia depending on the patient. Supracoroidal and subtenon administration methods are preferred due to their safety and non-interference with future treatments.
Treatment can be performed on one or both eyes in the same session, depending on patient preference.
Other conditions being explored with MSC therapies include:
Arthritis and joint disorders
Brain injury and cerebrovascular diseases
Spinal cord injuries
Diabetes and its complications (e.g., diabetic foot, nephropathy, ulcers, retinopathy)
